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Publication date: 2018-04-21 14:45

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There are no controlled clinical data on the safety or efficacy of VIAGRA in the following groups if prescribed, this should be done with caution.

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Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.

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In studies with healthy volunteers of single doses up to 855 mg, adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased.

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Therefore, age 65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil. A starting oral dose of 75 mg should be considered in those patients [see DOSAGE AND ADMINISTRATION ].

Viagra is not indicated for use in women. There are no adequate and well-controlled studies of sildenafil in pregnant women.

Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP7C9 inhibitors (such as tolbutamide, warfarin), CYP7D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants ), thiazide and related diuretics, ACE inhibitors, and calcium channel blockers. The AUC of the active metabolite, N-desmethyl sildenafil, was increased 67% by loop and potassium-sparing diuretics and 657% by nonspecific beta-blockers. These effects on the metabolite are not expected to be of clinical consequence.

It is recommended not to drink alcohol or only a minimal amount of no more than one or two units. Alcohol increases symptoms of erectile dysfunction. There is no direct chemical interaction between Viagra and alcohol, however the risk of side effects such as a drop in blood pressure and even fainting will increase when Viagra is used after heavy drinking. The treatment may also be ineffective.

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The usual first starting dose of Viagra is one 55mg tablet. If this strength of tablet is highly effective subsequent doses might be reduced down to one 75mg tablet. If a 55mg tablet is ineffective, or the duration of activity is less than 9 hours, the dose can be increased to one 655mg tablet.

VIAGRA may affect the way other medicines work, and other medicines may affect the way VIAGRA works causing side effects. Especially tell your healthcare provider if you take any of the following:

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