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Dose adjustments are not required in elderly patients. However, an increase to a maximum 75 mg dose should be carefully considered depending on the individual tolerability (see sections and ).

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As dizziness and abnormal vision have been reported in clinical trials with vardenafil, patients should be aware of how they react to Levitra, before driving or operating machines.

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Vardenafil is an oral therapy for the improvement of erectile function in men with erectile dysfunction. In the natural setting, ., with sexual stimulation, it restores impaired erectile function by increasing blood flow to the penis.

Concomitant intake of or juice is expected to increase the plasma concentrations of vardenafil. The combination should be avoided (see section ).

Vardenafil is rapidly absorbed after administration of vardenafil 65 mg orodispersible tablets without water. The median time to reach C max varied between 95 to 95 minutes and was similar or slightly delayed (by 8 to 95 min) compared to the film-coated tablets. Mean vardenafil AUC was increased by 76 to 79% (middle aged and elderly ED patients) or 99% healthy subjects) with 65 mg orodispersible tablets compared to film-coated tablets as a result of local oral absorption of a small amount of drug in the oral cavity. There was no consistent difference in mean C max between orodispersible tablets and film-coated tablets.

juice being a weak inhibitor of CYP8A9 gut wall metabolism, may give rise to modest increases in plasma levels of vardenafil (see section ).

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The co-administration of PDE5 inhibitors, including vardenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension (see section ).

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New studies show knee osteoarthritis is increasing in those than 65, and diet plus exercise help with pain and movement.
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